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IntelliGene
Active Role
Shared
PRECISION GENOMICS PLATFORM
Your genome.
Your blueprint for life.
Whole-genome intelligence combined with real-time wearable data. Powered by Azure AI Foundry + AutoGen multi-agent analysis.
How it works
๐Ÿงฌ
1. DNA Sample Collection
Saliva kit or blood draw at NPI lab. WGS 30ร— coverage.
โš™๏ธ
2. Genomic Processing
GATK4 pipeline โ†’ VCF โ†’ Ensembl VEP annotation inside TEE.
๐Ÿค–
3. AI Multi-Agent Analysis
5 specialist agents (Genomics, Cardiology, Neurology, Oncology, Longevity) generate your report.
๐Ÿ“Š
4. Continuous Intelligence
Wearable streams update your Digital Twin daily. Scores evolve with you.
Load Patient VCF File
๐Ÿ“
Click to select VCF file โ€” or drag & drop
Accepts: .vcf ยท .vcf.gz ยท Annotated with Ensembl VEP
Demo: Click "Load Demo Patient" to use the pre-loaded synthetic VCF (IG-2026-00001). In production, each patient's VCF is uploaded here โ€” parsed and analysed in <30 seconds.
Consent & Privacy
๐Ÿ”’
PDPA Thailand โ€” Consent Recorded
Granular consent for: Wellness analysis ยท Research opt-in ยท 72-hr deletion cascade (ยง33)
IntelliGene
โ— DEMO Ariya T.
AT
34.2
BIO AGE
Biological Age
3.8 years younger
than chronological
๐Ÿงฌ Horvath: 34.2
๐Ÿ”ฌ PhenoAge: 33.8
โฑ DunedinPACE: 0.82ร—
Chronological age: 38 ยท Female ยท Thai/SE Asian
Clocks require DNA methylation assay (Illumina EPIC) โ€” roadmap Phase 2
Live Wearable Data
DEMO โ€” hardcoded ยท Production: Apple Health + Oura OAuth
8,234
steps
Today
52
ms
HRV Avg
74
/100
Sleep Score
96
mg/dL
Fasting BG
Wellness Domains โ€” 10 active
Genomic Report
Patient ID: IG-2026-00001
Ariya Thongprasert
DOB: 1988-03-14 ยท Female ยท Thai/SE Asian
VCF processed: 2026-05-28
myvariant.info ClinVar gnomAD v4
What is a Polygenic Risk Score (PRS)?
A PRS combines hundreds of genetic variants โ€” each with a small effect โ€” into one score showing your relative risk vs the population. Example: Cardiovascular PRS at 72nd percentile means 72% of Thai/East Asian people have lower genetic cardiovascular risk than you. It identifies risk before symptoms appear โ€” enabling early preventive action.
Polygenic Risk Scores โ€” Thai/East Asian Reference (gnomAD v4 EAS, n=11,432)
Key Variants โ€” Evidence-Based Selection
Data Sources: Variant annotation via Ensembl VEP v111. Clinical significance from ClinVar (accessed 2026-05). Population frequencies from gnomAD v4 East Asian cohort (n=11,432). PGx from PharmGKB. Live enrichment via myvariant.info API.
Digital Twin
Phenome Simulator
What if you changed
your lifestyle?
Adjust the sliders below. Scores are recalculated based on your genotype + published intervention RCTs.
Lifestyle Interventions
๐Ÿƒ Exercise (min/week) 90
0WHO 150420
๐Ÿฅ— Diet Quality Score 6/10
PoorMediterraneanOptimal
๐ŸŒ™ Sleep Duration (hrs) 6.5h
4hOptimal 7โ€“9h10h
๐Ÿง˜ Stress Management Low
LowModerateHigh
Projected Impact
Evidence basis: Intervention effects modulated by your actual genotype (APOE, FTO, CLOCK, IL-6 variants). Sources: AHA meta-analysis (PMID:20301390), NEJM FTO exercise study (PMID:20075252), Sleep chronotype RCT (PMID:15364706).
Wearables Hub
2 connected
Connected Devices
๐ŸŽ
Apple Health
iPhone 16 Pro ยท Synced 14 min ago
8,234 steps
72 bpm avg
52ms HRV
Live
โ—Ž
Oura Ring Gen 4
Ring ยท Synced 2h ago
74 sleep
68 readiness
5.4ยฐC body temp
Live
๐Ÿ“Ÿ
Abbott Libre 3 (CGM)
Continuous Glucose Monitor
Connect
๐Ÿƒ
Garmin Connect
Sport & fitness metrics
Connect
FHIR R4 Observation Stream
Time
Resource
Value
Source
09:14:22
HeartRate
68 bpm
Apple Watch
08:52:01
Steps
2,341 steps
Apple Health
07:30:00
SleepStage
REM 22%, Deep 18%
Oura Ring
06:45:12
BodyTemperature
36.2ยฐC (+0.1 deviation)
Oura Ring
06:00:00
HRV
52 ms SDNN
Oura Ring
FHIR R4 pipeline: All wearable streams normalized to HL7 FHIR R4 Observation resources via Azure Health Data Services. Data enriches your Digital Twin in real time.
AI Insights
AutoGen ยท 5 Agents
๐Ÿค–
AutoGen Multi-Agent Report
Generated by Genomics ยท Cardiology ยท Neurology ยท Longevity agents. Confidence โ‰ฅ 0.82.
Multi-Agent AI Analysis
10 specialist agents ยท RAG-grounded ยท Evidence-cited
Pharmacogenomics Readiness
PGx Pre-Screen
Phase 3 โ€” Roadmap
CYP2C19 ยท CYP2D6 ยท CYP2C9 ยท SLCO1B1 ยท HLA-B panels identified. Warfarin/clopidogrel sensitivity variants present. Full PGx report requires clinical validation (Phase 3).
CYP2C19 *1/*17 CYP2D6 *1/*4 SLCO1B1 rs4149056 CT VKORC1 rs9923231 AG
Wellness Plan
12-week
Your Genotype-Guided
Action Plan
Personalized based on your variants. Updated weekly with wearable data.
This Week โ€” Focus Areas
12-Week Milestones
Weeks 1-3
Baseline calibration. Wearable sync. Sleep hygiene protocol for CLOCK CC genotype.
Weeks 4-6
Introduce Mediterranean diet protocol. FADS1 C/T โ†’ prioritize EPA/DHA supplementation (2g/day).
Weeks 7-9
Cardiovascular training block. ACTN3 R/X โ†’ endurance-biased program. Target 150 min/week Zone 2.
Weeks 10-12
Re-assess biological age clocks. Track inflammation markers via wearable HRV proxy. PRS score delta.
Privacy Centre
PDPA Compliant
โœ…
All data processing within Intel SGX TEE
Memory-encrypted compute. Remote attestation verified. Raw genomic data never exits the enclave.
Consent Dashboard โ€” PDPA Thailand
Wellness Analysis
Core genomic scoring & reporting
Wearable Data Sync
Apple Health, Oura Ring
Research Contribution
Thai population cohort (DP-protected, ฮต=1.0)
Physician Data Sharing
Share report with your assigned physician
Audit Trail โ€” Azure Confidential Ledger
๐Ÿ”—
Kit Issued โ†’ Sample Received
Block #4821 ยท 2026-05-22 ยท Hash: 0x3a8fโ€ฆ
๐Ÿ”—
GATK4 Alignment Completed
Block #4822 ยท 2026-05-24 ยท Hash: 0x7c2dโ€ฆ
๐Ÿ”—
VEP Annotation + VCF Delivered
Block #4823 ยท 2026-05-28 ยท Hash: 0x1e9aโ€ฆ
๐Ÿ”—
AI Report Generated + Signed
Block #4824 ยท 2026-05-28 ยท Hash: 0xb54fโ€ฆ
๐Ÿ”—
Physician Review Confirmed
Block #4825 ยท 2026-05-29 ยท Hash: 0x9d1cโ€ฆ
IntelliGene
Physician Portal
Dr
Patient Queue
3 pending review
Patient Bio Age Risk Flag Status
Ariya Thongprasert
IG-2026-00001 ยท Fยท38
 34.2 APOE ฮต3/ฮต4 Pending Review
Kamon Rattana
IG-2026-00002 ยท Mยท45
 49.1 BRCA2 VUS Pending Review
Siriporn Jaruwan
IG-2026-00003 ยท Fยท32
 29.4 Low Risk Signed Off
Thanawat Boonma
IG-2026-00004 ยท Mยท51
 47.6 T2D PRS 88th pct Pending Review
Ariya Thongprasert
Needs Sign-off
34.2
Bio Age
78
Cardio Score
64
Inflammation
58
Allergy Risk
Clinical Flags โ€” Requires Attention
โš ๏ธ
APOE ฮต3/ฮต4 โ€” Elevated Late-Onset Alzheimer's Risk
3โ€“4ร— population risk. ACMG Tier II. Genetic counseling recommended. Current cognitive score: 85 (above average).
๐Ÿ”ด
IL-6 rs1800795 C/G โ€” Chronic Inflammation Predisposition
Elevated IL-6 production. Inflammation domain: 64/100. Current HRV 52ms (borderline). Monitor CRP levels.
โ„น๏ธ
SLCO1B1 rs4149056 C/T โ€” Statin Myopathy Risk
If statin therapy initiated, consider low-dose rosuvastatin. Avoid simvastatin โ‰ฅ40mg. (PharmGKB Level 1A)
Physician Notes
IntelliGene
Corporate Dashboard
Population Analytics
De-identified ยท Differential Privacy ฮต=1.0 ยท 428 employees enrolled
36.2
Avg Bio Age
โˆ’2.3 yrs vs chrono
72
Avg Wellness
+4 pts QoQ
23%
High Cardio Risk
Action required
Domain Distribution Across Population
Cardiovascular
74
Metabolic
68
Cognitive
81
Sleep
62
Inflammation
58
Nutrition
71
Fitness
79
Top Intervention Opportunities
Sleep Hygiene Program
38% of employees have CLOCK variants โ†’ late chronotype
High ROI
Omega-3 Supplementation
52% FADS1 C/T or T/T โ€” reduced conversion efficiency
High ROI
Lactose Intolerance Meal Program
29% LCT G/G โ€” dairy-free cafeteria options
Medium ROI
Cardiovascular Screening
23% elevated PRS โ†’ early lipid panel & BP monitoring
Urgent
IntelliGene
System Nominal
Pipeline Status
VCF processing ยท AI Analysis ยท Vector DB ingestion
Active Job: IG-2026-00001
โœ“
VCF Validation & Ingestion
GATK4 GRCh38 ยท 4.2M variants ยท VQSR PASS filter ยท Completed 2026-05-28 14:02
โœ“
Ensembl VEP v111 Annotation
ClinVar ยท gnomAD v4 ยท PharmGKB ยท OMIM ยท dbNSFP 4.5 ยท 18,432 coding variants annotated
โœ“
myvariant.info Live Enrichment
REST API ยท 847 wellness-relevant variants queried ยท Confidence scores applied
โœ“
PRS Calculation
10 domains ยท GWAS Catalog weights ยท East Asian reference ยท PLINK2 compatible
โœ“
Epigenetic Age Clocks
Horvath ยท PhenoAge ยท GrimAge ยท DunedinPACE ยท Methylation imputed from WGS
โŸณ
AutoGen Multi-Agent Analysis
5 agents active (Genomics, Cardiology, Neurology, Longevity, Oncology) ยท GPT-4o ยท RAG on GWAS Catalog + PubMed
โ—‹
Vector DB Ingestion
DP-noise injection (ฮต=1.0) โ†’ Azure AI Search ยท Thai population cohort update
โ—‹
Physician Review Queue
Report sealed โ†’ Confidential Ledger block queued ยท Awaiting sign-off
System Health
TEE / SGX Enclave
AMD SEV-SNP ยท Attested โœ“
Azure Key Vault HSM
CMK rotation: 12 days
Sentinel SIEM
0 alerts (last 24h)
myvariant.info API
Latency: 142ms avg
Full Clinical Detail
Physician View
๐Ÿ” Role-Based Access โ€” Physician authentication required in production. Demo mode active.
34.2
Bio Age
78
Cardio Score
64
Inflammation
58
Allergy Risk
ACMG Secondary Findings โ€” 81-Gene Panel
โœ…
No pathogenic ACMG secondary findings detected
All 81 ACMG SF v3.2 genes screened. CHEK2 rs17879961 wild-type. HFE rs1800562 wild-type.
Complete Variant Analysis โ€” All 25 Variants
GenersIDGenotypeConsequenceClinVarThai/EAS FreqDomainACMG
APOErs429358T/C (ฮต3/ฮต4)missenseRisk Factor4.7%CardioยทCognitiveTier II
MTHFRrs1801133G/A (C677T)missenseLikely Path.36.2%CardioยทNutritionTier III
PCSK9rs11583680C/C (WT)missenseBenign2.1%Cardiovascularโ€”
FTOrs9939609T/T (WT)intronRisk Allele19.8%Metabolicโ€”
TCF7L2rs7903146C/TintronRisk Allele29.8%Metabolicโ€”
FADS1rs174546C/TintronRisk Allele22.8%Nutritionโ€”
LCTrs4988235A/AregulatoryPathogenic98.6%NutritionTier V
CLOCKrs1801260C/C (hom)3' UTRRisk Allele15.6%Sleepโ€”
IL6rs1800795G/CupstreamRisk Factor34.2%Inflammationโ€”
ACTN3rs1815739C/T (R577X)stop_gainedBenign41.1%Fitnessโ€”
MC1Rrs1805007C/TmissenseRisk Factor1.8%Skinโ€”
FCER1Ars2251746T/C5' UTRRisk Allele19.8%Allergyโ€”
BDNFrs6265G/A (Val66Met)missenseBenign48.3%Cognitiveโ€”
CYP2C19rs4244285G/A (*1/*2)splicePGx Actionable29.8%PGxTier I
SLCO1B1rs4149056T/CmissensePGx Actionable14.7%PGxTier I
VKORC1rs9923231G/AupstreamPGx31.2%PGxTier II
CHEK2rs17879961T/T (WT)missenseBenign0.3%OncologyTier V
HFErs1800562G/G (WT)missenseBenign0.8%OncologyTier V
PGx Drug Interaction Summary โ€” CPIC Level A
๐Ÿšซ Clopidogrel โ€” AVOID
CYP2C19 *1/*2 Intermediate Metaboliser โ€” 30-50% reduced efficacy. CPIC Level A.
High Priority
โ†’ Alternative: Prasugrel or Ticagrelor at standard dose
โš  Simvastatin โ€” USE WITH CAUTION
SLCO1B1 rs4149056 โ€” 4.5ร— myopathy risk. Avoid >20mg. CPIC Level A.
โ†’ Preferred: Rosuvastatin โ‰ค20mg/day
๐Ÿ“‹ Warfarin โ€” DOSE ADJUSTMENT
VKORC1 rs9923231 G/A โ€” reduce starting dose 20-30%. CPIC Level A.
โ†’ Target INR 2.0โ€“3.0 with reduced initial dose
Certify Report
Pending Signature
๐Ÿ” Digital signature in production uses PKI certificate bound to physician license. Timestamped and recorded on Azure Confidential Ledger.
Report ID: IGR-2026-00001-v1
Ariya Thongprasert
IG-2026-00001 ยท WGS ยท 2026-06-02 ยท 25 variants ยท 10 AI agents
QC: PASS
Coverage: 34.7ร—
ACMG: No secondary findings
Certifying Physician
Clinical Notes
Digital Signature
Click to apply digital signature
Production: PKI certificate ยท Timestamp Authority ยท Non-repudiation
Blockchain entry: Azure Confidential Ledger ยท Hash generated on sign
Send Back / Escalate
Action Required
๐Ÿ” All escalations are logged on the audit ledger with physician ID and timestamp.
Route this case to another party for additional information, re-analysis, or re-sequencing.
Send To
Issue Category
Priority
Notes to Recipient
IntelliGene
Institute Portal
BH
๐Ÿ” Role-Based Access โ€” Institute Admin credentials required in production. White-label branding applies to all patient-facing reports.
Bangkok Hospital Genomics
Partner Institute ยท IntelliGene White-label Plan ยท Active since 2026-04-01
47
Active Patients
8
Pending Reports
39
Certified Reports
Patient Activity
PatientStatusPhysicianAction
Ariya T.
IG-2026-00001
Physician ReviewDr. Wichai P.
Kamon R.
IG-2026-00002
Send BackDr. Supawit L.
Siriporn J.
IG-2026-00003
Certified โœ“Dr. Wichai P.
Thanawat B.
IG-2026-00004
VCF Processingโ€”
Institute Metrics
Avg report turnaround3.2 days
PGx actionable flags this month12
Patient satisfaction4.8 / 5.0
Reports certified this month14
White-label Reports
๐Ÿ” Patient-facing reports are generated with your institute's branding. IntelliGene branding is removed in white-label mode.
Brand Configuration
BH
Logo placeholder โ€” used on all reports and emails
Upload PNG/SVG in production
Report Preview
Bangkok Hospital Genomics Center
Whole Genome Wellness Report ยท AI-Powered Analysis
Report: IGR-2026-00001
2026-06-05
Ariya Thongprasert โ€” Biological Age: 34.2 years
10 wellness domains ยท 25 variants reviewed ยท 3 PGx flags ยท Certified by Dr. Wichai Pongpanich TMC-28741
A Bangkok Hospital Group Service ยท PDPA Compliant ยท Powered by IntelliGene AI
Patient Management
๐Ÿ” Manage patient enrollment, assign physicians, and track report lifecycle.
PatientEnrolledPhysicianStatusReport
Ariya Thongprasert
Fยท38 ยท IG-2026-00001
2026-05-20Dr. Wichai P.Physician ReviewPending
Kamon Rattana
Mยท45 ยท IG-2026-00002
2026-05-22Dr. Supawit L.Send BackOn Hold
Siriporn Jaruwan
Fยท32 ยท IG-2026-00003
2026-05-18Dr. Wichai P.CompleteCertified โœ“
Thanawat Boonma
Mยท51 ยท IG-2026-00004
2026-06-01Not assignedProcessingโ€”
Send Back / Feedback
2 open tickets
๐Ÿ” Institutes can escalate cases to physicians, IntelliGene AI, or the Genome Lab.
Open Requests
Ticket #SB-2026-00088 โ€” Kamon Rattana
Sent to: IntelliGene AI ยท BRCA2 VUS โ€” request deeper oncology analysis
Opened: 2026-06-04 ยท Status: In Progress
Urgent
Ticket #SB-2026-00085 โ€” Thanawat Boonma
Sent to: Genome Lab ยท Low coverage chr12 โ€” SLCO1B1 locus
Opened: 2026-06-02 ยท Status: Awaiting Lab Response
Raise New Request
IntelliGene
Genome Lab
NL
๐Ÿ” Lab Scientist credentials required. Handles VCF upload, QC validation, and variant certification before delivery to IntelliGene.
NPI Genomics Laboratory
ISO 15189 Accredited ยท GATK4 v4.4 ยท Illumina NovaSeq X ยท GRCh38
12
In Queue
3
Processing
8
VCF Ready
1
QC Failed
Processing Queue
Sample IDInstituteCoverageQCVCF Status
IG-2026-00001
Ariya T.
Bangkok Hospital34.7ร—PASSDelivered
IG-2026-00004
Thanawat B.
Bangkok Hospital28.1ร—ReviewPending
IG-2026-00005
New
BumrungradRunning...Processingโ€”
IG-2026-00003b
Re-seq request
Bangkok Hospital18.2ร—FAILRejected
Upload New VCF
๐Ÿ“ค
Upload VCF + QC Report
.vcf.gz ยท GATK4 HC ยท GRCh38 ยท With VEP annotation
Chain of Custody
Blockchain Verified
๐Ÿ” Every step from kit issue to VCF delivery recorded on Azure Confidential Ledger. Tamper-evident.
Sample: IG-2026-00001 ยท Ariya Thongprasert ยท Bangkok Hospital
Collected: 2026-05-20 ยท All 8 checkpoints verified
โœ“
Kit Issued to Patient
Kit #KIT-BH-2026-0441 ยท 2026-05-20 ยท Block #4820 ยท Hash: 0x2b1fโ€ฆ
โœ“
Sample Collected โ€” Blood Draw
Phlebotomist: N. Siriwan ยท Bangkok Hospital ยท 2026-05-20 14:30 ยท Block #4821
โœ“
Secure Logistics โ€” Cold Chain Transport
Courier #LC-0091 ยท 4ยฐC maintained ยท Received NPI Lab 2026-05-21 ยท Block #4822
โœ“
DNA Extraction & QC
260/280 ratio: 1.92 ยท Concentration: 85 ng/ยตL ยท PASS ยท Block #4822
โœ“
Illumina NovaSeq X โ€” WGS 30ร—
Run ID: NSX-2026-0891 ยท Coverage: 34.7ร— ยท Ti/Tv: 2.14 ยท Contamination: 0.2% ยท Block #4823
โœ“
GATK4 HaplotypeCaller โ†’ VCF
VQSR PASS ยท 4.2M variants ยท Ensembl VEP v111 ยท Block #4824 ยท 2026-05-28
โœ“
Lab Director Sign-off
Dr. Nattapong K. ยท PASS ยท Block #4825 ยท 2026-05-28
โœ“
VCF Delivered to IntelliGene
AES-256 encrypted ยท TEE ingestion confirmed ยท Block #4826 ยท 2026-05-28 17:42
Variant QC
PASS
๐Ÿ” Lab scientists review sequencing metrics before VCF delivery to IntelliGene.
Sequencing Quality โ€” IG-2026-00001
Mean Coverage
34.7ร—
โœ“ Exceeds 30ร— threshold
% Genome โ‰ฅ10ร—
98.7%
โœ“ Pass (โ‰ฅ97%)
Ti/Tv Ratio
2.14
โœ“ Normal (2.0โ€“2.2)
Sample Contamination
0.2%
โœ“ Pass (<2%)
Insert Size (median)
381 bp
โœ“ Normal
Duplicate Rate
8.3%
โœ“ Acceptable (<15%)
VQSR Summary
Total variants called4,218,441
VQSR PASS (SNPs)3,891,203
VQSR PASS (Indels)681,447
Filtered (low quality)145,791
Delivered to IntelliGene25 wellness variants
Feedback Inbox
1 action required
๐Ÿ” Physicians and institutes can send back cases requiring re-sequencing, QC review, or variant clarification.
Incoming Requests
Ticket #SB-2026-00085 โ€” Thanawat Boonma
From: Bangkok Hospital (Institute) ยท Low coverage on chr12:21178615 (SLCO1B1 locus) โ€” 8ร— insufficient for confident genotype call. Requesting targeted re-sequencing.
Received: 2026-06-02 ยท Priority: Normal
Open
Ticket #SB-2026-00079 โ€” Resolved โœ“
Dr. Wichai P. ยท CLOCK rs1801260 allele orientation โ€” Confirmed C allele on forward strand. 2026-06-01
Post Response